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Esta sexta edición, totalmente actualizada, pone especial énfasis en las nuevas clasificaciones de las neoplasias hematológicas elaboradas en 2022 (la clásica de la OMS y la International Consensus Classification,) y en los recientes hallazgos moleculares con implicaciones para el diagnóstico, el pronóstico y/o el tratamiento de las enfermedades de la sangre. Entre las novedades terapéuticas destacan la consolidación de la inmunoterapia en sus nuevas indicaciones, especialmente con los nuevos anticuerpos monoclonales biespecíficos, los anticuerpos inmunoconjugados y la terapia celular adoptiva con linfocitos T con receptor de antígeno quimérico. Además, se presentan los nuevos tratamientos de terapia génica aprobados para enfermedades hereditarias no neoplásicas como la anemia falciforme, la betatalasemia o la hemofilia. Se mantienen los resúmenes introductorios, que recogen los aspectos más importantes de cada capítulo, junto con las llamadas al margen, que destacan datos clave. Como en ediciones previas, se han resaltado y actualizado aquellos contenidos de reiterada aparición en el examen MIR. Las numerosas referencias cruzadas a lo largo del texto mantienen la uniformidad y la interrelación del contenido para transmitir un bloque de conocimientos integrado. Esta obra se ha consolidado a lo largo de los últimos 25 años entre los estudiantes españoles e hispanoamericanos de Medicina y Ciencias Biomédicas por su formato diferencial, basado en la formulación de los contenidos básicos de la hematología en forma de preguntas directas, eminentemente prácticas, seguidas de respuestas razonadas. Es también especialmente atractiva para profesionales biomédicos en formación y residentes de las diversas especialidades médicas.